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Plasmodium falciparum malaria

MedGen UID:
6185
•Concept ID:
C0024535
•
Disease or Syndrome
Synonyms: Malaria, Falciparum; Malaria, Plasmodium falciparum; Plasmodium falciparum Malaria
SNOMED CT: Falciparum malaria (62676009); Malignant tertian malaria (62676009); Malaria by Plasmodium falciparum (62676009); Subtertian malaria (62676009); Falciparum malaria - malignant (62676009); ST - Subtertian malaria (62676009); MT - Malignant tertian malaria (62676009); Pernicious malaria (62676009); STM - Subtertian malaria (62676009); MTM - Malignant tertian malaria (62676009); Plasmodium falciparum malaria (62676009); Malignant tertian fever (248441000)
 
Monarch Initiative: MONDO:0005920

Definition

Malaria resulting from infection by Plasmodium falciparum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlasmodium falciparum malaria

Professional guidelines

PubMed

Diagnosis and Treatment of Plasmodium vivax Malaria.
Baird JK, Valecha N, Duparc S, White NJ, Price RN
Am J Trop Med Hyg 2016 Dec 28;95(6 Suppl):35-51. Epub 2016 Oct 5 doi: 10.4269/ajtmh.16-0171. PMID: 27708191Free PMC Article
Management of severe paediatric malaria in resource-limited settings.
Maitland K
BMC Med 2015 Mar 3;13:42. doi: 10.1186/s12916-014-0263-6. PMID: 25858094Free PMC Article
Emergency department management of mosquito-borne illness: malaria, dengue, and West Nile virus.
Caraballo H, King K
Emerg Med Pract 2014 May;16(5):1-23; quiz 23-4. PMID: 25207355

Recent clinical studies

Etiology

Unpleasant Souvenir: Imported Plasmodium falciparum Malaria in Türkiye.
Özbilgin A, Tunalı V, Şenol Akar Ş, Çavuş İ, Zorbozan O, Yıldırım A, Turgay N
Turkiye Parazitol Derg 2023 Dec 27;47(4):204-208. doi: 10.4274/tpd.galenos.2023.99815. PMID: 38149439
Association between interleukin-27 gene polymorphisms and Plasmodium falciparum Malaria.
Aljarba NH, Al-Anazi MR, Al-Hazani TM, Shafeai MI, Rudiny FH, Motaen AM, Bin Dajem SM, Alothaid H, Alghamdi J, Alkahtani S, Al-Qahtani AA
Innate Immun 2023 Jul;29(5):83-94. Epub 2023 Jun 12 doi: 10.1177/17534259231178594. PMID: 37306242Free PMC Article
RTS,S/AS01 malaria vaccine-proven safe and effective?
Björkman A, Benn CS, Aaby P, Schapira A
Lancet Infect Dis 2023 Aug;23(8):e318-e322. Epub 2023 Apr 20 doi: 10.1016/S1473-3099(23)00126-3. PMID: 37086747
Iron deficiency and severe Plasmodium falciparum malaria.
Awah NW, Kaneko A
Clin Infect Dis 2012 Apr;54(8):1145-7. Epub 2012 Feb 21 doi: 10.1093/cid/cis020. PMID: 22354918Free PMC Article
Malarial hepatitis.
Kochar DK, Singh P, Agarwal P, Kochar SK, Pokharna R, Sareen PK
J Assoc Physicians India 2003 Nov;51:1069-72. PMID: 15260391

Diagnosis

Unpleasant Souvenir: Imported Plasmodium falciparum Malaria in Türkiye.
Özbilgin A, Tunalı V, Şenol Akar Ş, Çavuş İ, Zorbozan O, Yıldırım A, Turgay N
Turkiye Parazitol Derg 2023 Dec 27;47(4):204-208. doi: 10.4274/tpd.galenos.2023.99815. PMID: 38149439
CMOS Spectrophotometric Microsystem for Malaria Detection.
Ferreira GM, Baptista V, Silva V, Veiga MI, Minas G, Catarino SO
IEEE Trans Biomed Eng 2023 Aug;70(8):2318-2328. Epub 2023 Jul 18 doi: 10.1109/TBME.2023.3242691. PMID: 37022426
Fever in the Returning Traveler.
Paquet D, Jung L, Trawinski H, Wendt S, Lübbert C
Dtsch Arztebl Int 2022 Jun 7;119(22):400-407. doi: 10.3238/arztebl.m2022.0182. PMID: 35469592Free PMC Article
Extrinsic parameter's adjustment and potential implications in Plasmodium falciparum malaria diagnosis.
A V, B RK, C V
Microsc Res Tech 2022 Feb;85(2):685-696. Epub 2021 Sep 23 doi: 10.1002/jemt.23940. PMID: 34553808
Diagnosis and Treatment of Plasmodium vivax Malaria.
Baird JK, Valecha N, Duparc S, White NJ, Price RN
Am J Trop Med Hyg 2016 Dec 28;95(6 Suppl):35-51. Epub 2016 Oct 5 doi: 10.4269/ajtmh.16-0171. PMID: 27708191Free PMC Article

Therapy

Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria.
Blanchard A, Hine P
Emergencias 2023 Apr;35(2):139-141. doi: 10.55633/s3me/E082.2023. PMID: 37038945
Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
Datoo MS, Natama MH, Somé A, Traoré O, Rouamba T, Bellamy D, Yameogo P, Valia D, Tegneri M, Ouedraogo F, Soma R, Sawadogo S, Sorgho F, Derra K, Rouamba E, Orindi B, Ramos Lopez F, Flaxman A, Cappuccini F, Kailath R, Elias S, Mukhopadhyay E, Noe A, Cairns M, Lawrie A, Roberts R, Valéa I, Sorgho H, Williams N, Glenn G, Fries L, Reimer J, Ewer KJ, Shaligram U, Hill AVS, Tinto H
Lancet 2021 May 15;397(10287):1809-1818. Epub 2021 May 5 doi: 10.1016/S0140-6736(21)00943-0. PMID: 33964223Free PMC Article
Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria.
Blanshard A, Hine P
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD004529. doi: 10.1002/14651858.CD004529.pub3. PMID: 33459345Free PMC Article
Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria.
Isba R, Zani B, Gathu M, Sinclair D
Cochrane Database Syst Rev 2015 Feb 23;2015(2):CD011547. doi: 10.1002/14651858.CD011547. PMID: 25702785Free PMC Article
Vaccines against malaria.
Hill AV
Philos Trans R Soc Lond B Biol Sci 2011 Oct 12;366(1579):2806-14. doi: 10.1098/rstb.2011.0091. PMID: 21893544Free PMC Article

Prognosis

Association between interleukin-27 gene polymorphisms and Plasmodium falciparum Malaria.
Aljarba NH, Al-Anazi MR, Al-Hazani TM, Shafeai MI, Rudiny FH, Motaen AM, Bin Dajem SM, Alothaid H, Alghamdi J, Alkahtani S, Al-Qahtani AA
Innate Immun 2023 Jul;29(5):83-94. Epub 2023 Jun 12 doi: 10.1177/17534259231178594. PMID: 37306242Free PMC Article
Predictors of outcome in childhood Plasmodium falciparum malaria.
Patel H, Dunican C, Cunnington AJ
Virulence 2020 Dec;11(1):199-221. doi: 10.1080/21505594.2020.1726570. PMID: 32063099Free PMC Article
Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria.
Isba R, Zani B, Gathu M, Sinclair D
Cochrane Database Syst Rev 2015 Feb 23;2015(2):CD011547. doi: 10.1002/14651858.CD011547. PMID: 25702785Free PMC Article
Malaria: a haematological disease.
Akinosoglou KS, Solomou EE, Gogos CA
Hematology 2012 Mar;17(2):106-14. doi: 10.1179/102453312X13221316477336. PMID: 22664049
Plasmodium falciparum malaria.
Rees PH
East Afr Med J 1997 May;74(5):273-4. PMID: 9337000

Clinical prediction guides

Unpleasant Souvenir: Imported Plasmodium falciparum Malaria in Türkiye.
Özbilgin A, Tunalı V, Şenol Akar Ş, Çavuş İ, Zorbozan O, Yıldırım A, Turgay N
Turkiye Parazitol Derg 2023 Dec 27;47(4):204-208. doi: 10.4274/tpd.galenos.2023.99815. PMID: 38149439
RTS,S/AS01 malaria vaccine-proven safe and effective?
Björkman A, Benn CS, Aaby P, Schapira A
Lancet Infect Dis 2023 Aug;23(8):e318-e322. Epub 2023 Apr 20 doi: 10.1016/S1473-3099(23)00126-3. PMID: 37086747
Individual variation in Plasmodium vivax malaria risk: Are repeatedly infected people just unlucky?
Corder RM, Arez AP, Ferreira MU
PLoS Negl Trop Dis 2023 Jan;17(1):e0011020. Epub 2023 Jan 12 doi: 10.1371/journal.pntd.0011020. PMID: 36634044Free PMC Article
Predictors of outcome in childhood Plasmodium falciparum malaria.
Patel H, Dunican C, Cunnington AJ
Virulence 2020 Dec;11(1):199-221. doi: 10.1080/21505594.2020.1726570. PMID: 32063099Free PMC Article
Systems immunology of human malaria.
Tran TM, Samal B, Kirkness E, Crompton PD
Trends Parasitol 2012 Jun;28(6):248-57. Epub 2012 May 15 doi: 10.1016/j.pt.2012.03.006. PMID: 22592005Free PMC Article

Recent systematic reviews

Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.
Pryce J, Taylor M, Fox T, Hine P
Cochrane Database Syst Rev 2022 Jun 21;6(6):CD006404. doi: 10.1002/14651858.CD006404.pub4. PMID: 35726133Free PMC Article
Atovaquone-proguanil for treating uncomplicated Plasmodium falciparum malaria.
Blanshard A, Hine P
Cochrane Database Syst Rev 2021 Jan 15;1(1):CD004529. doi: 10.1002/14651858.CD004529.pub3. PMID: 33459345Free PMC Article
Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.
Zhou LJ, Xia J, Wei HX, Liu XJ, Peng HJ
Parasitol Res 2017 Feb;116(2):781-788. Epub 2016 Dec 27 doi: 10.1007/s00436-016-5353-2. PMID: 28028628
Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria.
Isba R, Zani B, Gathu M, Sinclair D
Cochrane Database Syst Rev 2015 Feb 23;2015(2):CD011547. doi: 10.1002/14651858.CD011547. PMID: 25702785Free PMC Article
Thrombocytopenia in malaria: who cares?
Lacerda MV, Mourão MP, Coelho HC, Santos JB
Mem Inst Oswaldo Cruz 2011 Aug;106 Suppl 1:52-63. doi: 10.1590/s0074-02762011000900007. PMID: 21881757

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